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  • Hallucinogens, like LSD or psilocybin mushrooms, are a group of drugs that alter perceptions of the environment, thoughts, and feelings. Taking hallucinogens can result in visual hallucinations and feeling disconnected from the body. 

    Drinking alcohol while taking hallucinogens can be dangerous because the effects of both substances can be unpredictable. Mixing them can worsen side effects and increase the risk of alcohol poisoning or drug overdose. 

    Effects Of Hallucinogens

    Hallucinogens are a class of psychedelic drugs that include classic hallucinogens and dissociative drugs. These drugs commonly cause hallucinations and, in the case of dissociative drugs, can also cause you to feel detached from reality. 

    Hallucinogenic drugs include:

    The effects of each drug vary but can occur within a few minutes and last several hours. The altered sense of perception and hallucinations that commonly occur are referred to as a “trip.” Some people have frightening experiences while taking hallucinogens, known as a “bad trip.

    Classic hallucinogens can cause the following side effects:

    • increased heart rate
    • nausea
    • intense feelings
    • altered sense of time

    Dissociative drugs can cause the following side effects:

    • increased heart rate
    • increased blood pressure
    • high body temperature
    • numbness
    • memory impairment
    • inability to move
    • disorientation
    • seizures
    • difficulty breathing

    Effects Of Alcohol

    Alcohol is a depressant drug that, in moderation, can make you feel more relaxed and lower inhibitions. However, alcohol abuse can lead to more severe side effects that interfere with judgment, coordination, and memory. 

    Short-term effects of alcohol include:

    Someone may drink alcohol while taking hallucinogens to lower the adverse effects associated with the drug. However, when mixed with other drugs or in excessive amounts, alcohol can cause severe or life-threatening side effects. 

    Dangers Of Mixing Alcohol & Hallucinogens

    The effects of hallucinogens, even when taken alone, may not be consistent. It’s difficult to know how your body will react and if you will experience severe side effects. A combination of alcohol and hallucinogens can cause dangerous drug interactions.

    Adverse Effects

    As the effects of hallucinogens wear off, you may experience the uncomfortable effects associated with a comedown. A comedown can cause a wide range of feelings, such as anxiety, depression, and fatigue. 

    Some people may drink alcohol to ease the effects of a comedown. However, drinking alcohol when hallucinogens are still in your system can worsen these symptoms. 

    Mixing drugs also increases the risk of severe side effects, including nausea and vomiting. 

    Long-Term Effects

    Alcohol can worsen symptoms of mental health disorders, including anxiety and depression. In addition, long-term drug use can impair thinking, memory, and speech. Over time, hallucinogens may also increase paranoia, anxiety, and depression. 

    Long-term alcohol use can also negatively impact physical health. Alcohol abuse increases the risk of liver damage, high blood pressure, heart problems, and several types of cancer. 

    Alcohol Poisoning

    Hallucinogens can interfere with your ability to appropriately gauge the effects of alcohol intoxication. 

    According to a study in the National Library of Medicine, the majority of people who mixed alcohol with hallucinogens reported blocked or reduced effects of alcohol. This can cause you to unintentionally drink too much alcohol, which increases the risk of alcohol poisoning

    Alcohol poisoning can be life-threatening and may cause the following symptoms:

    • confusion
    • sedation
    • nausea/vomiting
    • seizures
    • difficulty breathing
    • bluish skin tone
    • loss of consciousness


    Overdose can occur with hallucinogens, especially dissociative drugs if you take too much or mix them with other substances. 

    Dissociative drugs, like PCP, should never be combined with central nervous system depressant drugs, including alcohol, opioids, and benzodiazepines, because of the increased risk of respiratory depression. 

    If you recognize signs of respiratory depression, like slowed breathing, heart rate, or loss of consciousness, seek medical attention immediately. 


    Long-term substance abuse increases the risk of developing a drug or alcohol addiction. Addiction also referred to as a substance use disorder (SUD), is characterized by a loss of control over drug or alcohol use. 

    According to the National Institute on Drug Abuse (NIDA), the dissociative drug PCP has been associated with a high risk of addiction. If you suddenly stop using PCP, you may experience withdrawal symptoms, including cravings, headaches, and sweating. 

    Alcohol use can also lead to dependence and addiction, which is likely to result in withdrawal symptoms if you suddenly stop. Alcohol withdrawal can be life-threatening and may cause seizures, tremors, and hallucinations. 

    Substance Use Disorder Treatment

    Drug addiction treatment centers offer a wide range of services, including detox, inpatient, and outpatient programs. These programs are beneficial for helping you learn to cope with cravings and manage life without the use of substances. 

    Most treatment centers integrate a variety of therapeutic groups and activities, which may include behavioral therapy, 12-step facilitation, individual counseling, and meditation. 

    If you or a loved one would like to know more about treatment options, please call our helpline today.

    Related Topics

    What Happens When You Mix MDMA & Alcohol? 

    Mixing MDMA and alcohol can lead to prolonged euphoria, but it can also lead to organ damage, risky behavior, and addiction.

    Learn more about Mixing MDMA And Alcohol

    What Happens When You Mix LSD & Alcohol?

    Mixing LSD and alcohol can lead to several serious side effects including hallucinations, nausea and vomiting, and blackouts. It can also increase the risk of alcohol poisoning.

    Learn more about Mixing LSD & Alcohol

    What Happens When You Drink Alcohol On Shrooms?

    When you drink alcohol and take shrooms, you can experience a variety of side effects including panic attacks, seizures, or vomiting. 

    Because alcohol is a depressant and causes a lack of self-awareness and shrooms cause a change in perception, you can easily forget how much you’re drinking which can lead to alcohol poisoning, blackouts, and mental health concerns. 

    Learn more about Mixing Alcohol & Shrooms

    Written by Ark Behavioral Health Editorial Team
    ©2024 Ark National Holdings, LLC. | All Rights Reserved.
    This page does not provide medical advice.

    Centers For Disease Control And Prevention (CDC) - Alcohol Use And Your Health
    National Institute On Drug Abuse (NIDA) - Hallucinogens DrugFacts
    National Institute On Drug Abuse (NIDA) - What Are the Effects of Common Dissociative Drugs on the Brain and Body?
    National Library Of Medicine - Hallucinogenic Drugs Attenuate The Subjective Response To Alcohol In Humans

    Medically Reviewed by
    Kimberly Langdon M.D.
    on April 27, 2022
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