Mixing Seroquel & Adderall | Effects & Risks

Quetiapine and dextroamphetamine/amphetamine (brand names Seroquel and Adderall, respectively) are prescription drugs used to treat different health issues. Mixing different drugs can have serious results.
For instance, Seroquel is an atypical antipsychotic medication used to help treat symptoms of schizophrenia, certain instances of bipolar depression and manic episodes in people diagnosed with bipolar disorder and treatment-resistant major depressive disorder.
Adderall and the extended-release Adderall XR is a stimulant drug used to treat symptoms of those with attention deficit hyperactivity disorder ADHD. Additionally, Adderall may help treat the sleeping disorder narcolepsy.
At low doses, these stimulant and antipsychotic drugs may be combined without any drug interactions taking place. However, mixing Seroquel and Adderall must be carefully monitored by your prescribing doctor.
Side Effects Of Combining Seroquel & Adderall
When combined properly with the assistance of a healthcare professional, Seroquel and Adderall may assist with ADHD. In fact, stimulant and antipsychotic medications are commonly used together. Nonetheless, both drugs may cause side effects.
Common Side Effects
Some of the common and shared side effects of these medications include:
- drowsiness
- dry mouth
- sedation
- constipation
- headache
Serious Side Effects
Those who participate in Seroquel and Adderall abuse may experience more serious side effects, including:
- fluctuations in heart rate
- high blood pressure
- weight gain
- the worsening of mental health problems including psychosis
- withdrawal symptoms
- overdose
Risks Of Combining Seroquel & Adderall
Seroquel and Adderall abuse can lead to serious complications to one’s health. There are various risks associated with combining these medications, including interactions with other drugs and a risk of overdose.
Drug Interactions
While Seroquel and Adderall may be combined successfully, this may not be the case with other substances. Those seeking to combine the drugs to achieve a “high” may also try to add other substances to their system.
Serious drug interactions may take place if the directions provided by your doctor are not followed. Meds and substances to avoid, according to the United States Food and Drug Administration (FDA), include:
- central nervous system (CNS) depressants and benzodiazepines like alprazolam (Xanax) and clonazepam (Klonopin)
- antidepressants such as selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs)
- alcohol
- over-the-counter pain medications
- aripiprazole (Abilify)
- stimulants
- risperidone
- olanzapine (Zyprexa)
According to the United States Drug Enforcement Administration (DEA), Seroquel is not a controlled substance while Adderall is a Schedule II controlled substance. Much care must be taken while using these two drugs, as a potential overdose may occur when substance abuse takes place.
Overdose
Combining any medication can lead to adverse effects. However, abusing a drug may lead to a potential overdose. Some of the signs of an overdose from Seroquel or Adderall consist of:
- drowsiness
- dizziness
- fainting
- seizures
- cardiovascular symptoms
If you suspect an overdose has taken place, be sure to reach out for medical attention and contact 911 immediately.
FAQ
What Happens If You Mix Seroquel & Adderall?
Those who combine Seroquel (quetiapine) and Adderall (amphetamine/dextroamphetamine) as directed by their doctor may find successful treatment for certain health conditions. However, when the drugs are abused, serious side effects may take place.
If you or a loved one live with prescription drug addiction, our healthcare professionals can help. To learn about what we do, please contact us today.
Written by Ark Behavioral Health Editorial Team
©2025 Ark National Holdings, LLC. | All Rights Reserved.
This page does not provide medical advice.
Food and Drug Administration - Adderall
Food and Drug Administration - Seroquel
National Library of Medicine: MedlinePlus - Dextroamphetamine and Amphetamine
National Library of Medicine: MedlinePlus - Quetiapine
Psychiatry - The Dopamine Dilemma
Psychiatry - The Dopamine Dilemma Pt 2
Therapeutic Advances in Psychopharmacology - Low-dose quetiapine complements stimulant response in attention deficit hyperactivity disorder and more
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