• For 24/7 Treatment Help Call

    (800) 526-5053

  • When used together in a medical setting at therapeutic doses, stimulants and opioid drugs are known to provide more effective and manageable pain relief than can be achieved with opioid drugs alone. However, this is not the case when either drug is abused and taken at higher doses.

    There is no safe way to recreationally mix drugs of abuse. Whether the drugs are pulling the body in the same direction or opposite directions, the wide-ranging effects of polydrug abuse can be devastating and unpredictable.

    The Difference Between Adderall & Opiates

    Adderall is a prescription central nervous system (CNS) stimulant that contains both amphetamine and dextroamphetamine. It is primarily used to treat attention deficit hyperactivity disorder (ADHD) as well as narcolepsy.

    Ritalin, another common medication used to treat ADHD and narcolepsy, is similar to Adderall but uses the active ingredient methylphenidate, works, and peaks more quickly, and only lasts for about two to three hours, rather than four to six.

    Opioids or opiates, on the other hand, are a family of analgesic drugs related to opium, and act as CNS depressants. When used, opioids change the way the brain interprets pain, providing moderate to strong pain relief along with a habit-forming euphoria at high doses.

    Various opioid (or opiate) drugs vary widely in terms of potency and medical use. A few especially well-known opioid drugs include fentanyl, heroin, oxycodone (OxyContin), hydrocodone (Vicodin), codeine, and methadone.

    Amphetamines & Opioids In Therapeutic Use

    According to evidence provided by a number of studies, stimulant drugs, including amphetamine, may increase the effect of opioids while decreasing drowsiness and cognitive impairment.

    In one study, researchers gave cancer patients who used opioid painkillers for chronic pain management 25 mg of methylphenidate daily. They were then able to increase the daily morphine-equivalent opioid dosage for these patients from 248 mg to 405 mg, allowing for better pain management without severe side effects.

    However, most healthcare professionals today are hesitant to prescribe psychostimulants to patients using other prescription drugs, even at carefully controlled therapeutic doses, because of the potential for abuse or dependence. 

    Polydrug Abuse

    Unfortunately, Adderall and other stimulant medications are commonly abused, as are opioid drugs. And when taken together, these opposed substances can trigger an intense dopamine rush and long-lasting euphoria.

    This is a form of polydrug abuse, the effects of which can be unpredictable and vary depending on which substances are taken together.

    Stimulant + Stimulant

    If a stimulant is abused with another stimulant (e.g. Adderall and cocaine, or Ritalin and methamphetamine) the effect will accelerate physical and mental activity to dangerous levels, more so than if the drugs are abused alone. 

    This can result in heart attacks, delirium, and other potentially life-threatening symptoms. 

    Depressant + Depressant

    If a depressant is abused with another depressant (e.g. heroin, a benzodiazepine like valium, oxycodone, or alcohol) CNS activity may become dangerously suppressed, with heart rate, breathing, and blood pressure dropping to dangerous levels or ceasing altogether. 

    Stimulant + Depressant

    When a stimulant is taken with a depressant it creates what is known as a push-pull effect. While Adderall will pull blood pressure and heart rate higher, the opioid compounds will attach to opioid receptors, pushing the body to relax and suppress heart rate and breathing.

    As mentioned, at therapeutic doses this balancing effect can be beneficial. But at high doses, the stress of these conflicting effects can be deeply punishing on the body and mind, leading to a wide variety of harmful short- and long-term health effects.

    Health Effects Of Mixing Adderall & Opioids

    Health effects associated with mixing high doses of Adderall (and other stimulants) and opioid drugs include:

    • increased likelihood of developing dependence on the various substances involved, contributing to development of substance use disorder (drug addiction)
    • sudden CNS changes as drugs are absorbed and metabolized at different rates, causing sudden swings in bodily activity due to changing sedation or stimulant effects
    • mental health changes, including confusion, incoherence, blurred vision, stupor, and paranoia
    • uncontrolled and uncoordinated motor activity
    • increased risk of overdose
    • increased risk of potentially fatal heart attack, aneurysm, respiratory failure, or stroke, resulting from rapid changes in CNS activity
    • long-term cognitive, physical, and psychological degradation

    Polysubstance Abuse Treatment

    Both stimulants and opioids are intensely habit forming when abused, and using both at the same time can trigger particularly severe forms of substance use disorder. 

    Personalized inpatient addiction treatment may begin with medical detox as patients are assisted through their withdrawal symptoms in a safe and supportive environment. Treatment then progresses through various forms of therapy, often including:

    • medication-assisted treatment
    • individual and group counseling
    • cognitive-behavioral therapy
    • education and other supportive services
    • aftercare

    To learn more, please contact Ark Behavioral Health today. 

    Written by Ark Behavioral Health Editorial Team
    ©2024 Ark National Holdings, LLC. | All Rights Reserved.
    This page does not provide medical advice.

    Florida Alcohol and Drug Abuse Association (FADAA) - “Speed-balling”: Mixing Stimulants and Opioids Micro-module (fadaa.org)
    National Institute on Drug Abuse (NIDA) - Prescription Stimulants DrugFacts
    National Institute on Drug Abuse (NIDA) - Real Teens Ask About Speedballs
    National Institute on Drug Abuse (NIDA) - What classes of prescription drugs are commonly misused?

    Medically Reviewed by
    Kimberly Langdon M.D.
    on March 16, 2021
    Questions About Treatment?

    Ark Behavioral Health offers 100% confidential substance abuse assessment and treatment placement tailored to your individual needs. Achieve long-term recovery.

    100% confidential. We respect your privacy.
    Prefer Texting?

    Our friendly support team is here to chat 24/7. Opt out any time.


    Our Facilities

    Premier Drug Rehab & Mental Health Care Facilities In Massachusetts & Ohio

    Bedrock Recovery

    Canton, MA

    • Medical detox
    • Inpatient & Residential Treatment
    • Primary Mental Health Care
    • Movie Theater & Fitness Center

    Learn More

    Northeast Addictions

    Quincy, MA

    • Day treatment program
    • Intensive Outpatient Program
    • Full-Day Group Therapy
    • Easy Access to Public Transit

    Learn More

    Spring Hill Recovery Center

    Ashby, MA

    • Residential Treatment
    • Gender-Specific Residencies
    • Outdoor Recreation
    • Expansive 70-Acre Campus

    Learn More

    Ohio Recovery Center

    Van Wert, OH

    • Medical Detox
    • Residential Treatment
    • Primary Mental Health Care
    • 55-Acre Campus

    Learn More

    For Immediate Treatment Help Call 800-526-5053